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We are grateful to T Schroeder for the p141CAG-3SIP vector, W Droege and A Roscher for helpful discussions

Actin Sequestration & Cell Migration T4 works by sequestering actin monomers (G-actin), which regulates cell motility and enables rapid wound closure

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It is used in the treatment and prevention of vitamin B12 deficiency in patients with conditions such as: Addisonian (pernicious) anemia Malabsorption Atrophic gastritis Prolonged treatment with metformin Small bowel bacterial overgrowth (SIBO) Total or partial gastrectomy Infection with the fish parasite Diphyllobothrium latum Helicobacter pylori infection Pancreatic dysfunction Pancreatic or bowel malignancy Dietary deficiency (e.g